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Dong-Woo LEE personal link
Associate Professor / Yonsei University
LEEHICAM@YONSEI.AC.KR
Prof. Lee received his doctorate in Biotechnology from Yonsei University, Seoul, Korea in 2004 and completed his postdoctoral training at the University of Pennsylvania in 2010. He has been a senior research scientist of Korea Research Institute of Bioscience & Biotechnology from 2010-2012, and joined the faculty at the Kyungpook National University from 2012-2018. He has been appointed as Yonsei University faculty since 2018. He has served as editorial board member of Frontiers in Microbiology since 2011, Frontiers in Chemistry since 2016, and a deputy editor of the Journal of Microbiology and Biotechnology since 2018.
His lab strives to understand the structure-function relationship of primordial enzymes, and to define the factors governing the thermostability and substrate specificity of extremozymes engaged in sugar isomerization, protein degradation, and redox catalysis. His lab is also involved in exploring the anaerobic metabolism of extremophiles under harsh environments, and defining the thresholds of minimal cellular function and molecular adaptation. Toward this aim, his group employs a variety of advanced multi-omics technologies including the next-generation sequencing, directed evolution, and MS2 spectroscopy to understand how extremophiles have been evolved under harsh environments. In parallel to these investigations, his group is exploring the possibility of creating much promiscuous and thermostable versions of the highly specific and thermolabile counterparts to reveal the minimal requirements for function. The goal is to design and engineer protein that will provide a variety of repertoires of non-natural enzyme activity, potentiating the design and development of novel biological processes for industrial applications. Such bold and highly innovative new research approaches have enabled him to make significant contributions to our scientific societies, which has been well recognized and appreciated based on the fact that since 1999, he has had more than 70 scientific publications in high quality, peer-reviewed journals. Additionally, he has been invited to present his work orally over 40 times at international scientific meetings.
His lab strives to understand the structure-function relationship of primordial enzymes, and to define the factors governing the thermostability and substrate specificity of extremozymes engaged in sugar isomerization, protein degradation, and redox catalysis. His lab is also involved in exploring the anaerobic metabolism of extremophiles under harsh environments, and defining the thresholds of minimal cellular function and molecular adaptation. Toward this aim, his group employs a variety of advanced multi-omics technologies including the next-generation sequencing, directed evolution, and MS2 spectroscopy to understand how extremophiles have been evolved under harsh environments. In parallel to these investigations, his group is exploring the possibility of creating much promiscuous and thermostable versions of the highly specific and thermolabile counterparts to reveal the minimal requirements for function. The goal is to design and engineer protein that will provide a variety of repertoires of non-natural enzyme activity, potentiating the design and development of novel biological processes for industrial applications. Such bold and highly innovative new research approaches have enabled him to make significant contributions to our scientific societies, which has been well recognized and appreciated based on the fact that since 1999, he has had more than 70 scientific publications in high quality, peer-reviewed journals. Additionally, he has been invited to present his work orally over 40 times at international scientific meetings.