Dr. Lee is a Principal Scientist and the Director of Synthetic Biology Research Center in Korea Research Institute of Biosciences and Biotechnology (KRIBB). Lee abtained a Ph.D. in Biotechnology from the KAIST(1995), where he studied of thermophilic enzyme engineering and optimization algorithm for enzyme reactors. He has worked as a research scientist in KRIBB since 1996. He was also a postdoc in Chemistry of Pennsylvania State University during 2001-2003, where he studied to evolve functional hybrid enzymes. Since then, he has focused on enzyme evolution based on high throughput technologies; particularly he initiated the artificial genetic circuit project for single cell evolution using flow cytometry. The genetic circuits was to convert variety of enzyme activities to fluorescence signals. His team is currently interested in the expansion of genetic circuit uses for biosensors, enzyme engineering, and also for the smart regulation of metabolic pathways. His achievements was awarded by Presidential Medal of Korea in 2019.